The In Vitro Evaluation of Povidone-Iodine Against Multiple Ocular Adenoviral Types.

ABSTRACT:

Purpose

Povidone-iodine (P-I) is being touted as a topical antiviral treatment for eye infections caused by adenovirus (Ad). This study evaluated the in vitro antiviral activity of the several P-I concentrations previously used in clinical studies against multiple ocular Ad types commonly associated with eye infections.

Methods

The antiviral activity of four concentrations of P-I was compared to vehicle for seven types of Ad after incubating the P-I with Ad at 33°C for various lengths of time. Following incubation and neutralization of the P-I with sodium thiosulfate, viral titers were determined for each Ad type and time point.

Results

Virucidal (99.9%, ≥3-Log₁₀) reductions in titers were produced for 5%, 2%, and 0.4% P-I at 1 min for types Ad5 and Ad7a. S

SUBMITTER: Yates KA 

PROVIDER: S-EPMC6450451 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature