Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.
Ontology highlight
ABSTRACT: Impact statement
Extracellular matrix (ECM) biomaterials were used to treat esophageal cancer patients after cancer resection and promoted regrowth of normal mucosa without recurrence of cancer. The present study investigates the mechanisms by which these materials were successful to prevent the cancerous phenotype. ECM downregulated neoplastic esophageal cell function (proliferation, metabolism), but normal esophageal epithelial cells were unaffected in vitro, and suggests a molecular basis (downregulation of PI3K-Akt, cell cycle) for the promising clinical results. The therapeutic effect appeared to be enhanced using homologous esophageal ECM. This study suggests that ECM can be further investigated to treat cancer patients after resection or in combination with targeted therapy.
SUBMITTER: Saldin LT
PROVIDER: S-EPMC6450457 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.
Saldin Lindsey T LT Patel Shil S Zhang Li L Huleihel Luai L Hussey George S GS Nascari David G DG Quijano Lina M LM Li Xue X Raghu Divya D Bajwa Anant K AK Smith Nicholas G NG Chung Christopher C CC Omstead Ashten N AN Kosovec Juliann E JE Jobe Blair A BA Turner Neill J NJ Zaidi Ali H AH Badylak Stephen F SF
Tissue engineering. Part A 20190301 5-6
<h4>Impact statement</h4>Extracellular matrix (ECM) biomaterials were used to treat esophageal cancer patients after cancer resection and promoted regrowth of normal mucosa without recurrence of cancer. The present study investigates the mechanisms by which these materials were successful to prevent the cancerous phenotype. ECM downregulated neoplastic esophageal cell function (proliferation, metabolism), but normal esophageal epithelial cells were unaffected <i>in vitro</i>, and suggests a mole ...[more]
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