Ontology highlight
ABSTRACT:
SUBMITTER: Ziegler AN
PROVIDER: S-EPMC6450461 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ziegler Amber N AN Feng Qiang Q Chidambaram Shravanthi S Testai Jaimie M JM Kumari Ekta E Rothbard Deborah E DE Constancia Miguel M Sandovici Ionel I Cominski Tara T Pang Kevin K Gao Nan N Wood Teresa L TL Levison Steven W SW
Stem cell reports 20190321 4
Tissue-specific stem cells have unique properties and growth requirements, but a small set of juxtacrine and paracrine signals have been identified that are required across multiple niches. Whereas insulin-like growth factor II (IGF-II) is necessary for prenatal growth, its role in adult stem cell physiology is largely unknown. We show that loss of Igf2 in adult mice resulted in a ∼50% reduction in slowly dividing, label-retaining cells in the two regions of the brain that harbor neural stem cel ...[more]