Ontology highlight
ABSTRACT:
SUBMITTER: Pearce KH
PROVIDER: S-EPMC6450522 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Pearce Kenneth H KH Overton Laurie K LK Gampe Robert T RT Barrett George B GB Taylor J David JD McKee David D DD Campobasso Nino N Nolte Robert T RT Reid Robert A RA
Acta crystallographica. Section F, Structural biology communications 20190313 Pt 4
Furin, also called proprotein convertase subtilisin/kexin 3 (PCSK3), is a calcium-dependent serine endoprotease that processes a wide variety of proproteins involved in cell function and homeostasis. Dysregulation of furin has been implicated in numerous disease states, including cancer and fibrosis. Mammalian cell expression of the furin ectodomain typically produces a highly glycosylated, heterogeneous protein, which can make crystallographic studies difficult. Here, the expression and purific ...[more]