Ontology highlight
ABSTRACT:
SUBMITTER: Chinoy ZS
PROVIDER: S-EPMC6450558 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chinoy Zoeisha S ZS Bodineau Clément C Favre Camille C Moremen Kelley W KW Durán Raúl V RV Friscourt Frédéric F
Angewandte Chemie (International ed. in English) 20190219 13
The metabolic oligosaccharide engineering (MOE) strategy using unnatural sialic acids has recently enabled the visualization of the sialome in living systems. However, MOE only reports on global sialylation and dissected information regarding subsets of sialosides is missing. Described here is the synthesis and utilization of sialic acids modified with a sydnone reporter for the metabolic labeling of sialoconjugates. The positioning of the reporter on the sugar significantly altered its metaboli ...[more]