Ontology highlight
ABSTRACT:
SUBMITTER: Saykali B
PROVIDER: S-EPMC6450669 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Saykali Bechara B Mathiah Navrita N Nahaboo Wallis W Racu Marie-Lucie ML Hammou Latifa L Defrance Matthieu M Migeotte Isabelle I
eLife 20190405
In mouse embryo gastrulation, epiblast cells delaminate at the primitive streak to form mesoderm and definitive endoderm, through an epithelial-mesenchymal transition. Mosaic expression of a membrane reporter in nascent mesoderm enabled recording cell shape and trajectory through live imaging. Upon leaving the streak, cells changed shape and extended protrusions of distinct size and abundance depending on the neighboring germ layer, as well as the region of the embryo. Embryonic trajectories wer ...[more]