Ontology highlight
ABSTRACT:
SUBMITTER: Itkin T
PROVIDER: S-EPMC6450701 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Itkin Tomer T Gur-Cohen Shiri S Spencer Joel A JA Schajnovitz Amir A Ramasamy Saravana K SK Kusumbe Anjali P AP Ledergor Guy G Jung Yookyung Y Milo Idan I Poulos Michael G MG Kalinkovich Alexander A Ludin Aya A Kollet Orit O Shakhar Guy G Butler Jason M JM Rafii Shahin S Adams Ralf H RH Scadden David T DT Lin Charles P CP Lapidot Tsvee T
Nature 20160413 7599
Bone marrow endothelial cells (BMECs) form a network of blood vessels that regulate both leukocyte trafficking and haematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs balance these dual roles, and whether these events occur at the same vascular site. We found that mammalian bone marrow stem cell maintenance and leukocyte trafficking are regulated by distinct blood vessel types with different permeability properties. Less permeable arterial blood vessels ...[more]