Detecting Modifications in Proteomics Experiments with Param-Medic.
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ABSTRACT:
SUBMITTER: May DH
PROVIDER: S-EPMC6450762 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Detecting Modifications in Proteomics Experiments with Param-Medic.
May Damon H DH Tamura Kaipo K Noble William S WS
Journal of proteome research 20190305 4
Searching tandem mass spectra against a peptide database requires accurate knowledge of various experimental parameters, including machine settings and details of the sample preparation protocol. In some cases, such as in reanalysis of public data sets, this experimental metadata may be missing or inaccurate. We describe a method for automatically inferring the presence of various types of modifications, including stable-isotope and isobaric labeling and tandem mass tags as well as the enrichmen ...[more]
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