Ontology highlight
ABSTRACT:
SUBMITTER: Doonan J
PROVIDER: S-EPMC6451002 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Doonan James J Tarafdar Anuradha A Pineda Miguel A MA Lumb Felicity E FE Crowe Jenny J Khan Aneesah M AM Hoskisson Paul A PA Harnett Margaret M MM Harnett William W
Nature communications 20190405 1
The human immune system has evolved in the context of our colonisation by bacteria, viruses, fungi and parasitic helminths. Reflecting this, the rapid eradication of pathogens appears to have resulted in reduced microbiome diversity and generation of chronically activated immune systems, presaging the recent rise of allergic, autoimmune and metabolic disorders. Certainly, gastrointestinal helminths can protect against gut and lung mucosa inflammatory conditions by modulating the microbiome and s ...[more]