Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.
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ABSTRACT:
SUBMITTER: Jones SE
PROVIDER: S-EPMC6451011 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.
Jones Samuel E SE van Hees Vincent T VT Mazzotti Diego R DR Marques-Vidal Pedro P Sabia Séverine S van der Spek Ashley A Dashti Hassan S HS Engmann Jorgen J Kocevska Desana D Tyrrell Jessica J Beaumont Robin N RN Hillsdon Melvyn M Ruth Katherine S KS Tuke Marcus A MA Yaghootkar Hanieh H Sharp Seth A SA Ji Yingjie Y Harrison Jamie W JW Freathy Rachel M RM Murray Anna A Luik Annemarie I AI Amin Najaf N Lane Jacqueline M JM Saxena Richa R Rutter Martin K MK Tiemeier Henning H Kutalik Zoltán Z Kumari Meena M Frayling Timothy M TM Weedon Michael N MN Gehrman Philip R PR Wood Andrew R AR
Nature communications 20190405 1
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10<sup>-8</sup>, of which 20 reach a stricter threshold of P < 8 × 10<sup>-10</sup>. These include 26 novel associations with measures of sleep qua ...[more]
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