Pathology of white matter integrity in three major white matter fasciculi: A post-mortem study of schizophrenia and treatment status.

ABSTRACT:

Background and purpose

Imaging studies have shown that people with schizophrenia exhibit abnormal connectivity termed "dysconnectivity" in several white matter tracts, including the cingulum bundle (CB), corpus callosum (CC), and arcuate fasciculus (AF). This study aimed to elucidate potential contributors to schizophrenia "dysconnectivity."

Experimental approach

Western blot analysis was used to compare protein levels of myelin basic protein, neurofilament heavy, autophagosome marker LC3, and microtubule marker α-tubulin in post-mortem human CB, CC, and AF in schizophrenia subjects (SZ) and matched normal controls (NC). Additionally, SZ cases were subdivided by treatment status: off-medication (OFF) or on-medication (ON).

Key results

In the CC, the combined SZ group

SUBMITTER: Schoonover KE 

PROVIDER: S-EPMC6451068 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature