Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.
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ABSTRACT:
SUBMITTER: Pellegrino S
PROVIDER: S-EPMC6451132 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.
Pellegrino Simone S Meyer Mélanie M Könst Zef A ZA Holm Mikael M Voora Vamsee K VK Kashinskaya Daniya D Zanette Camila C Mobley David L DL Yusupova Gulnara G Vanderwal Chris D CD Blanchard Scott C SC Yusupov Marat M
Nucleic acids research 20190401 6
Natural products that target the eukaryotic ribosome are promising therapeutics to treat a variety of cancers. It is therefore essential to determine their molecular mechanism of action to fully understand their mode of interaction with the target and to inform the development of new synthetic compounds with improved potency and reduced cytotoxicity. Toward this goal, we have previously established a short synthesis pathway that grants access to multiple congeners of the lissoclimide family. Her ...[more]
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