Dataset Information

Exploring the use of adjusted body mass index thresholds based on equivalent insulin resistance for defining overweight and obesity in UK South Asian children.

ABSTRACT:

Background

Body mass index (BMI) overweight/obesity thresholds in South Asian (SA) adults, at equivalent type-2 diabetes risk are lower than for white Europeans (WE). We aimed to define adjusted overweight/obesity thresholds for UK-SA children based on equivalent insulin resistance (HOMA-IR) to WE children.

Methods

In 1138 WE and 1292 SA children aged 9.0-10.9 years, multi-level regression models quantified associations between BMI and HOMA-IR by ethnic group. HOMA-IR levels for WE children were calculated at established overweight/obesity thresholds (at 9.5 years and 10.5 years), based on UK90 BMI cut-offs. Quantified associations in SA children were then used to estimate adjusted SA weight-status thresholds at the calculated HOMA-IR levels.

Results

At 9.5 years, current WE BMI overweight and obesity thresholds were 19.2 kg/m², 21.3 kg/m² (boys) and 20.0 kg/m², 22.5 kg/m² (girls). At equivalent HOMA-IR, SA overweight and obesity thresholds were lower by 2.9 kg/m² (95% CI: 2.5-3.3 kg/m²) and 3.2 kg/m² (95% CI: 2.7-3.6 kg/m²) in boys and 3.0 kg/m² (95% CI: 2.6-3.4 kg/m²) and 3.3 kg/m² (95% CI: 2.8-3.8 kg/m²) in girls, respectively. At these lower thresholds, overweight/obesity prevalences in SA children were approximately doubled (boys: 61%, girls: 56%). Patterns at 10.5 years were similar.

Conclusions

SA adjusted overweight/obesity thresholds based on equivalent IR were markedly lower than BMI thresholds for WE children, and defined more than half of SA children as overweight/obese.

SUBMITTER: Hudda MT

PROVIDER: S-EPMC6451638 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Publications

Exploring the use of adjusted body mass index thresholds based on equivalent insulin resistance for defining overweight and obesity in UK South Asian children.

Hudda Mohammed T MT Donin Angela S AS Owen Christopher G CG Rudnicka Alicja R AR Sattar Naveed N Cook Derek G DG Whincup Peter H PH Nightingale Claire M CM

International journal of obesity (2005) 20181213 7

<h4>Background</h4>Body mass index (BMI) overweight/obesity thresholds in South Asian (SA) adults, at equivalent type-2 diabetes risk are lower than for white Europeans (WE). We aimed to define adjusted overweight/obesity thresholds for UK-SA children based on equivalent insulin resistance (HOMA-IR) to WE children.<h4>Methods</h4>In 1138 WE and 1292 SA children aged 9.0-10.9 years, multi-level regression models quantified associations between BMI and HOMA-IR by ethnic group. HOMA-IR levels for W ...[more]

PMID: 30546135

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Dataset Information

Exploring the use of adjusted body mass index thresholds based on equivalent insulin resistance for defining overweight and obesity in UK South Asian children.

Background

Methods

Results

Conclusions

Publications

Exploring the use of adjusted body mass index thresholds based on equivalent insulin resistance for defining overweight and obesity in UK South Asian children.

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