Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients.
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ABSTRACT:
SUBMITTER: Bins S
PROVIDER: S-EPMC6451710 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients.
Bins Sander S Huitema Alwin D R ADR Laven Pim P Bouazzaoui Samira El SE Yu Huixin H van Erp Nielka N van Herpen Carla C Hamberg Paul P Gelderblom Hans H Steeghs Neeltje N Sleijfer Stefan S van Schaik Ron H N RHN Mathijssen Ron H J RHJ Koolen Stijn L W SLW
Clinical pharmacokinetics 20190501 5
<h4>Background and objective</h4>As pazopanib plasma trough concentrations are correlated with treatment outcome, we explored whether single nucleotide polymorphisms in the elimination pathway of pazopanib affect systemic pazopanib concentrations.<h4>Methods</h4>The decreased function alleles CYP3A4 15389 C > T (*22), ABCB1 3435 C >T, ABCG2 421 C >A, and ABCG2 34G >A were analyzed within a recently developed population-pharmacokinetic model.<h4>Results</h4>Incorporation of CYP3A4*22 in the model ...[more]
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