Ontology highlight
ABSTRACT:
SUBMITTER: Meilleur CE
PROVIDER: S-EPMC6452305 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Meilleur Courtney E CE Wardell Christine M CM Mele Tina S TS Dikeakos Jimmy D JD Bennink Jack R JR Mu Hong-Hua HH McCormick John K JK Haeryfar S M Mansour SMM
The Journal of infectious diseases 20190401 8
Superantigens (SAgs) released by common Gram-positive bacterial pathogens have been reported to delete, anergize, or activate mouse T cells. However, little is known about their effects on preexisting memory CD8+ T cell (TCD8) pools. Furthermore, whether SAgs manipulate human memory TCD8 responses to cognate antigens is unknown. We used a human peripheral blood mononuclear cell culture system and a nontransgenic mouse model in which the impact of stimulation by two fundamentally distinct SAgs, s ...[more]