Dataset Information

Genetic Evidence of Focal Plasmodium falciparum Transmission in a Pre-elimination Setting in Southern Province, Zambia.

ABSTRACT:

Background

Southern Province, Zambia has experienced a dramatic decline in Plasmodium falciparum malaria transmission in the past decade and is targeted for elimination. Zambia's National Malaria Elimination Program recommends reactive case detection (RCD) within 140 m of index households to enhance surveillance and eliminate remaining transmission foci.

Methods

To evaluate whether RCD captures local transmission, we genotyped 26 microsatellites from 106 samples collected from index (n = 27) and secondary (n = 79) cases detected through RCD in the Macha Hospital catchment area between January 2015 and April 2016.

Results

Participants from the same RCD event harbored more genetically related parasites than those from different RCD events, suggesting that RCD captures, at least in part, infections related through local transmission. Related parasites clustered in space and time, up to at least 250 m from index households. Spatial analysis identified a putative focal transmission hotspot.

Conclusions

The current RCD strategy detects focal transmission events, although programmatic guidelines to screen within 140 m of index households may fail to capture all secondary cases. This study highlights the utility of parasite genetic data in assessing programmatic interventions, and similar approaches may be useful to malaria elimination programs seeking to tailor intervention strategies to the underlying transmission epidemiology.

SUBMITTER: Pringle JC

PROVIDER: S-EPMC6452320 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Genetic Evidence of Focal Plasmodium falciparum Transmission in a Pre-elimination Setting in Southern Province, Zambia.

Pringle Julia C JC Tessema Sofonias S Wesolowski Amy A Chen Anna A Murphy Maxwell M Carpi Giovanna G Shields Timothy M TM Hamapumbu Harry H Searle Kelly M KM Kobayashi Tamaki T Katowa Ben B Musonda Michael M Stevenson Jennifer C JC Thuma Philip E PE Greenhouse Bryan B Moss William J WJ Norris Douglas E DE

The Journal of infectious diseases 20190401 8

<h4>Background</h4>Southern Province, Zambia has experienced a dramatic decline in Plasmodium falciparum malaria transmission in the past decade and is targeted for elimination. Zambia's National Malaria Elimination Program recommends reactive case detection (RCD) within 140 m of index households to enhance surveillance and eliminate remaining transmission foci.<h4>Methods</h4>To evaluate whether RCD captures local transmission, we genotyped 26 microsatellites from 106 samples collected from ind ...[more]

PMID: 30445612

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Dataset Information

Genetic Evidence of Focal Plasmodium falciparum Transmission in a Pre-elimination Setting in Southern Province, Zambia.

Background

Methods

Results

Conclusions

Publications

Genetic Evidence of Focal Plasmodium falciparum Transmission in a Pre-elimination Setting in Southern Province, Zambia.

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