Ontology highlight
ABSTRACT:
SUBMITTER: Crist M
PROVIDER: S-EPMC6452591 | biostudies-literature | 2019 Jan-Dec
REPOSITORIES: biostudies-literature
Crist Michael M Iyer Gopa G Hsu Miles M Huang William C WC Huang William C WC Balar Arjun V AV
Therapeutic advances in urology 20190101
The treatment of advanced urothelial carcinoma (UC) has dramatically changed with the advent of immune checkpoint inhibitors that disrupt the T-cell inhibitory interaction between the programmed cell death (PD)-1 receptor and its ligand (PD-L1). Pembrolizumab, a highly specific, monoclonal antibody directed against PD-1, has demonstrated clinical efficacy as well as a favorable toxicity profile, and has emerged as a new standard of care in the treatment of advanced UC. This review will summarize ...[more]