Ontology highlight
ABSTRACT:
SUBMITTER: Rico F
PROVIDER: S-EPMC6452689 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Rico Felix F Russek Andreas A González Laura L Grubmüller Helmut H Scheuring Simon S
Proceedings of the National Academy of Sciences of the United States of America 20190319 14
Receptor-ligand interactions are essential for biological function and their binding strength is commonly explained in terms of static lock-and-key models based on molecular complementarity. However, detailed information on the full unbinding pathway is often lacking due, in part, to the static nature of atomic structures and ensemble averaging inherent to bulk biophysics approaches. Here we combine molecular dynamics and high-speed force spectroscopy on the streptavidin-biotin complex to determ ...[more]