Dataset Information

Fast scrambling on sparse graphs.

ABSTRACT: Given a quantum many-body system with few-body interactions, how rapidly can quantum information be hidden during time evolution? The fast-scrambling conjecture is that the time to thoroughly mix information among N degrees of freedom grows at least logarithmically in N. We derive this inequality for generic quantum systems at infinite temperature, bounding the scrambling time by a finite decay time of local quantum correlations at late times. Using Lieb-Robinson bounds, generalized Sachdev-Ye-Kitaev models, and random unitary circuits, we propose that a logarithmic scrambling time can be achieved in most quantum systems with sparse connectivity. These models also elucidate how quantum chaos is not universally related to scrambling: We construct random few-body circuits with infinite Lyapunov exponent but logarithmic scrambling time. We discuss analogies between quantum models on graphs and quantum black holes and suggest methods to experimentally study scrambling with as many as 100 sparsely connected quantum degrees of freedom.

SUBMITTER: Bentsen G

PROVIDER: S-EPMC6452717 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Fast scrambling on sparse graphs.

Bentsen Gregory G Gu Yingfei Y Lucas Andrew A

Proceedings of the National Academy of Sciences of the United States of America 20190321 14

Given a quantum many-body system with few-body interactions, how rapidly can quantum information be hidden during time evolution? The fast-scrambling conjecture is that the time to thoroughly mix information among N degrees of freedom grows at least logarithmically in N. We derive this inequality for generic quantum systems at infinite temperature, bounding the scrambling time by a finite decay time of local quantum correlations at late times. Using Lieb-Robinson bounds, generalized Sachdev-Ye-K ...[more]

PMID: 30898887

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Project description:Protein design algorithms enumerate a combinatorial number of candidate structures to compute the Global Minimum Energy Conformation (GMEC). To efficiently find the GMEC, protein design algorithms must methodically reduce the conformational search space. By applying distance and energy cutoffs, the protein system to be designed can thus be represented using a sparse residue interaction graph, where the number of interacting residue pairs is less than all pairs of mutable residues, and the corresponding GMEC is called the sparse GMEC. However, ignoring some pairwise residue interactions can lead to a change in the energy, conformation, or sequence of the sparse GMEC vs. the original or the full GMEC. Despite the widespread use of sparse residue interaction graphs in protein design, the above mentioned effects of their use have not been previously analyzed. To analyze the costs and benefits of designing with sparse residue interaction graphs, we computed the GMECs for 136 different protein design problems both with and without distance and energy cutoffs, and compared their energies, conformations, and sequences. Our analysis shows that the differences between the GMECs depend critically on whether or not the design includes core, boundary, or surface residues. Moreover, neglecting long-range interactions can alter local interactions and introduce large sequence differences, both of which can result in significant structural and functional changes. Designs on proteins with experimentally measured thermostability show it is beneficial to compute both the full and the sparse GMEC accurately and efficiently. To this end, we show that a provable, ensemble-based algorithm can efficiently compute both GMECs by enumerating a small number of conformations, usually fewer than 1000. This provides a novel way to combine sparse residue interaction graphs with provable, ensemble-based algorithms to reap the benefits of sparse residue interaction graphs while avoiding their potential inaccuracies.

Dataset Information

Fast scrambling on sparse graphs.

Publications

Fast scrambling on sparse graphs.

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