Ontology highlight
ABSTRACT:
SUBMITTER: E X
PROVIDER: S-EPMC6452726 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
E Xiaofei X Meraner Paul P Lu Ping P Perreira Jill M JM Aker Aaron M AM McDougall William M WM Zhuge Ronghua R Chan Gary C GC Gerstein Rachel M RM Caposio Patrizia P Yurochko Andrew D AD Brass Abraham L AL Kowalik Timothy F TF
Proceedings of the National Academy of Sciences of the United States of America 20190320 14
A human cytomegalovirus (HCMV) pentameric glycoprotein complex (PC), gH-gL-UL128-UL130-UL131A, is necessary for viral infection of clinically relevant cell types, including epithelial cells, which are important for interhost transmission and disease. We performed genome-wide CRISPR/Cas9 screens of different cell types in parallel to identify host genes specifically required for HCMV infection of epithelial cells. This effort identified a multipass membrane protein, OR14I1, as a receptor for HCMV ...[more]