Ontology highlight
ABSTRACT:
SUBMITTER: Debarnot C
PROVIDER: S-EPMC6452739 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Debarnot Claire C Monneau Yoan R YR Roig-Zamboni Véronique V Delauzun Vincent V Le Narvor Christine C Richard Emeline E Hénault Jérôme J Goulet Adeline A Fadel Firas F Vivès Romain R RR Priem Bernard B Bonnaffé David D Lortat-Jacob Hugues H Bourne Yves Y
Proceedings of the National Academy of Sciences of the United States of America 20190314 14
Heparan sulfate (HS) is a linear, complex polysaccharide that modulates the biological activities of proteins through binding sites made by a series of Golgi-localized enzymes. Of these, glucuronyl C5-epimerase (Glce) catalyzes C5-epimerization of the HS component, d-glucuronic acid (GlcA), into l-iduronic acid (IdoA), which provides internal flexibility to the polymer and forges protein-binding sites to ensure polymer function. Here we report crystal structures of human Glce in the unbound stat ...[more]