Ontology highlight
ABSTRACT:
SUBMITTER: Wieser M
PROVIDER: S-EPMC6453361 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wieser Matthias M Francisci Teresa T Lackner Daniel D Buerckstuemmer Tilmann T Wasner Kamilla K Eilenberg Wolf W Stift Anton A Wahrmann Markus M Böhmig Georg A GA Grillari Johannes J Grillari-Voglauer Regina R
PloS one 20190408 4
The kidney is especially sensitive to diseases associated with overactivation of the complement system. While most of these diseases affect kidney glomeruli and the microvasculature, there is also evidence for tubulointerstitial deposition of complement factors. Complement inactivating factors on cell membranes comprise CD55, CD59 and CD46, which is also termed membrane cofactor protein (MCP). CD46 has been described as localized to glomeruli, but especially also to proximal tubular epithelial c ...[more]