Ontology highlight
ABSTRACT:
SUBMITTER: Kowalski PS
PROVIDER: S-EPMC6453548 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Molecular therapy : the journal of the American Society of Gene Therapy 20190219 4
mRNA has broad potential as a therapeutic. Current clinical efforts are focused on vaccination, protein replacement therapies, and treatment of genetic diseases. The clinical translation of mRNA therapeutics has been made possible through advances in the design of mRNA manufacturing and intracellular delivery methods. However, broad application of mRNA is still limited by the need for improved delivery systems. In this review, we discuss the challenges for clinical translation of mRNA-based ther ...[more]