Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy.
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ABSTRACT:
SUBMITTER: Rahman SA
PROVIDER: S-EPMC6453747 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Relationship between endogenous melatonin concentrations and uterine contractions in late third trimester of human pregnancy.
Rahman Shadab A SA Bibbo Carolina C Olcese James J Czeisler Charles A CA Robinson Julian N JN Klerman Elizabeth B EB
Journal of pineal research 20190310 4
In humans, circulating levels of the hormone melatonin and the initiation of spontaneous labor are both higher at night than during the day. Since activation of uterine melatonin receptors can stimulate human in vitro uterine contractions and these receptors are only expressed on the uterine tissue of women in labor, we hypothesized that circulating melatonin concentrations would affect uterine contractions in vivo. We evaluated the impact of light-induced modulation of melatonin secretion on ut ...[more]
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