Ontology highlight
ABSTRACT:
SUBMITTER: Huijbers EJM
PROVIDER: S-EPMC6455290 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Huijbers Elisabeth J M EJM van der Werf Inge M IM Faber Lisette D LD Sialino Lena D LD van der Laan Pia P Holland Hanna A HA Cimpean Anca M AM Thijssen Victor L J L VLJL van Beijnum Judy R JR Griffioen Arjan W AW
Frontiers in immunology 20190402
CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker for Ewing's Sarcoma (EWS), as it is highly expressed by these tumors. It has been reported that CD99 can affect the migration, invasion and metastasis of tumor cells. Our results show that CD99 is also highly expressed in the tumor vasculature o ...[more]