Ontology highlight
ABSTRACT:
SUBMITTER: Depaoli MR
PROVIDER: S-EPMC6456002 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Depaoli Maria R MR Karsten Felix F Madreiter-Sokolowski Corina T CT Klec Christiane C Gottschalk Benjamin B Bischof Helmut H Eroglu Emrah E Waldeck-Weiermair Markus M Simmen Thomas T Graier Wolfgang F WF Malli Roland R
Cell reports 20181001 2
Reprogramming of metabolic pathways determines cell functions and fate. In our work, we have used organelle-targeted ATP biosensors to evaluate cellular metabolic settings with high resolution in real time. Our data indicate that mitochondria dynamically supply ATP for glucose phosphorylation in a variety of cancer cell types. This hexokinase-dependent process seems to be reversed upon the removal of glucose or other hexose sugars. Our data further verify that mitochondria in cancer cells have i ...[more]