Ontology highlight
ABSTRACT:
SUBMITTER: Lin Y
PROVIDER: S-EPMC6456258 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Lin Yi Y Marin-Argany Marta M Dick Christopher J CJ Redhage Keely R KR Blancas-Mejia Luis M LM Bulur Peggy P Butler Greg W GW Deeds Michael C MC Madden Benjamin J BJ Williams Angela A Wall Jonathan S JS Dietz Allan A Ramirez-Alvarado Marina M
Cytotherapy 20171014 12
<h4>Background aims</h4>Light chain (AL) amyloidosis is a protein misfolding disease characterized by extracellular deposition of immunoglobulin light chains (LC) as amyloid fibrils. Patients with LC amyloid involvement of the heart have the worst morbidity and mortality. Current treatments target the plasma cells to reduce further production of amyloid proteins. There is dire need to understand the mechanisms of cardiac tissue damage from amyloid to develop novel therapies. We recently reported ...[more]