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Royal jelly attenuates cadmium-induced nephrotoxicity in male mice.


ABSTRACT: Cadmium exposure induces nephrotoxicity by mediating oxidative stress, inflammation, and apoptosis. The purpose of this study was to examine the protective effect of royal jelly on Cd-induced nephrotoxicity. Adult male mice were distributed randomly into 4 clusters: untreated, royal jelly-treated (85?mg/kg, oral), CdCl2-treated (6.5?mg/kg, intraperitoneal), and pretreated with royal jelly (85?mg/kg) 2?h before CdCl2 injection (6.5?mg/kg, intraperitoneal) for seven consecutive days. Cd concentration in the renal tissue and absolute kidney weight of the Cd-treated mice were significantly higher than those of control group. The levels of kidney function markers, kidney injury molecules-1 (KIM-1), metallothionein, lipid peroxidation, nitric oxide, tumor necrosis factor-?, interleukin-1?, and the apoptosis regulators Bax and caspases-3 also increased significantly in the renal tissue of Cd-treated mice, whereas the levels of glutathione, antioxidant enzyme activities, and the apoptosis inhibitor Bcl-2 were significantly reduced in the renal tissue of Cd-treated group. Histopathological studies showed vacuolation and congested glomeruli in the kidney tissue of Cd-treated mice. However, all aforementioned Cd-induced changes were attenuated by pretreatment with royal jelly. We therefore concluded that royal jelly attenuated Cd-induced nephrotoxicity and it is suggested that this nephroprotective effect could be linked to its ability to promote the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant responsive element (ARE) pathway.

SUBMITTER: Almeer RS 

PROVIDER: S-EPMC6456607 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Royal jelly attenuates cadmium-induced nephrotoxicity in male mice.

Almeer Rafa S RS   AlBasher Gadah I GI   Alarifi Saud S   Alarifi Saud S   Alkahtani Saad S   Ali Daoud D   Abdel Moneim Ahmed E AE  

Scientific reports 20190409 1


Cadmium exposure induces nephrotoxicity by mediating oxidative stress, inflammation, and apoptosis. The purpose of this study was to examine the protective effect of royal jelly on Cd-induced nephrotoxicity. Adult male mice were distributed randomly into 4 clusters: untreated, royal jelly-treated (85 mg/kg, oral), CdCl<sub>2</sub>-treated (6.5 mg/kg, intraperitoneal), and pretreated with royal jelly (85 mg/kg) 2 h before CdCl<sub>2</sub> injection (6.5 mg/kg, intraperitoneal) for seven consecuti  ...[more]

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