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Joint modeling of multivariate hearing thresholds measured longitudinally at multiple frequencies.


ABSTRACT: Pure-tone thresholds are used to estimate hearing acuity and, when measured longitudinally, can characterize age-related changes in hearing. Measured at multiple-frequencies, multiple-irregular time points, for right and left ears, these longitudinal studies of age-related hearing loss produce data of inherent complexity due to: 1) multivariate outcomes at different frequencies; 2) longitudinal measurements taken at subject-specific time intervals; and 3) inter-ear correlations due to clustering and nesting. To address limitations in existing methods, we propose a multivariate generalized linear mixed model(mGLMM) and assess its performance. We demonstrate its application using a unique dataset from a cohort study of age-related hearing loss.

SUBMITTER: Gebregziabher M 

PROVIDER: S-EPMC6456904 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Joint modeling of multivariate hearing thresholds measured longitudinally at multiple frequencies.

Gebregziabher Mulugeta M   Eckert Mark A MA   Matthews Lois J LJ   Teklehaimanot Abeba A AA   Dubno Judy R JR  

Communications in statistics: theory and methods 20180307 22


Pure-tone thresholds are used to estimate hearing acuity and, when measured longitudinally, can characterize age-related changes in hearing. Measured at multiple-frequencies, multiple-irregular time points, for right and left ears, these longitudinal studies of age-related hearing loss produce data of inherent complexity due to: 1) multivariate outcomes at different frequencies; 2) longitudinal measurements taken at subject-specific time intervals; and 3) inter-ear correlations due to clustering  ...[more]

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