Ontology highlight
ABSTRACT:
SUBMITTER: Liao J
PROVIDER: S-EPMC6456926 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Liao Jiling J Jiang Juan J Jun Heejin H Qiao Xiaona X Emont Margo P MP Kim Dong-Il DI Wu Jun J
Endocrinology 20180701 7
It has been reported that class I histone deacetylase (HDAC) inhibition increases thermogenesis in fat, but adipocyte-specific Hdac3 deletions have presented inconsistent results. In this study, we observed that HDAC3 protein levels were lower in brown fat compared with inguinal subcutaneous adipose tissue, and they decreased in both fat depots upon cold exposure. PR domain-containing 16 (PRDM16) physically interacted with HDAC3, and treatment with HDAC3-selective inhibitor RGFP966 induced therm ...[more]