Unknown

Dataset Information

0

The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta.

ABSTRACT: Using data from five independent vaccine trials, which employed a subunit cocktail vaccine containing eight recombinant proteins to protect sheep against Teladorsagia circumcincta, a strategy was developed to simplify antigen complexity of the vaccine. A meta-analysis of data from these five trials demonstrated statistically significant reductions in cumulative faecal egg count and worm burden in vaccinated sheep when compared with those which had received adjuvant only (P?=?0.009 and P?

SUBMITTER: Nisbet AJ 

PROVIDER: S-EPMC6456928 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

The rational simplification of a recombinant cocktail vaccine to control the parasitic nematode Teladorsagia circumcincta.

Nisbet Alasdair J AJ   McNeilly Tom N TN   Price Daniel R G DRG   Oliver E Margaret EM   Bartley Yvonne Y   Mitchell Mairi M   Palarea-Albaladejo Javier J   Matthews Jacqueline B JB  

International journal for parasitology 20190126 3-4

Using data from five independent vaccine trials, which employed a subunit cocktail vaccine containing eight recombinant proteins to protect sheep against Teladorsagia circumcincta, a strategy was developed to simplify antigen complexity of the vaccine. A meta-analysis of data from these five trials demonstrated statistically significant reductions in cumulative faecal egg count and worm burden in vaccinated sheep when compared with those which had received adjuvant only (P = 0.009 and P < 0.0001  ...[more]

Similar Datasets

Unknown Characterisation of a niche-specific excretory-secretory peroxiredoxin from the parasitic nematode Teladorsagia circumcincta.
| S-EPMC6617597 | biostudies-literature
Unknown A preliminary proteomic characterisation of extracellular vesicles released by the ovine parasitic nematode, Teladorsagia circumcincta.
| S-EPMC4867787 | biostudies-literature
Unknown Infection with the sheep gastrointestinal nematode Teladorsagia circumcincta increases luminal pathobionts.
| S-EPMC7193420 | biostudies-literature
Unknown Niche-specific gene expression in a parasitic nematode; increased expression of immunomodulators in Teladorsagia circumcincta larvae derived from host mucosa.
| S-EPMC5543109 | biostudies-literature
Genomics Teladorsagia circumcincta
| PRJNA72693 | ENA
Genomics Teladorsagia circumcincta
| PRJNA219637 | ENA
Transcriptomics Teladorsagia circumcincta transcriptomics
2015-06-30 | E-ERAD-342 | biostudies-arrayexpress
Unknown Novel gene expression responses in the ovine abomasal mucosa to infection with the gastric nematode Teladorsagia circumcincta.
| S-EPMC3135528 | biostudies-literature
Unknown A highly conserved, inhibitable astacin metalloprotease from Teladorsagia circumcincta is required for cuticle formation and nematode development.
| S-EPMC4406453 | biostudies-literature
Unknown Exploring the abomasal lymph node transcriptome for genes associated with resistance to the sheep nematode Teladorsagia circumcincta.
| S-EPMC3751673 | biostudies-literature