Dataset Information

Serum Level of Total Lipids and Telomere Length in the Male Population: A Cross-Sectional Study.

ABSTRACT: Telomeres contain TTAGGG (T; Thymine, A; Adenine and G; Guanine) repetitive sequences and are placed at the end of human chromosomes. Telomere dysfunction is implicated in some age-related and chronic diseases, but its association with total serum lipids and obesity is unknown. Our objective was to determine influenced of total serum lipids on leukocyte telomere lengths (TLs). Participants were selected by cluster sampling from 22 districts of Tehran. The questionnaires were completed by 500 subjects and after the initial assessment in terms of lifestyle, nutrition, home, and job, 300 healthy people, aged 25-40 years were finally selected. TLs and serum level of total lipids were measured by quantitative real-time PCR and the Phillips method, respectively. The average telomere length (T/S) and total lipids were 1.05 ± 0.3 mg/dl and 643.3 ± 70.8 mg/dl, respectively. We found that a one unit difference in the following parameters were associated with kilo base pair differences in TL: Age -0.0002 (95% CI [-0.0022, -0.0018]), BMI -0.0019 (95% CI [-0.0003, -0.0034]), TC 0.0001 (95% CI [-0.0006, -0.0007]), TG -0.0010 (95% CI [-0.0015, -0.0004]), PL 0.0001 (95% CI [-0.0005, -0.0007]), and TSL -0.0003 (95% CI [-0.0008, 0.0001]). Spearman correlation analysis revealed an inverse relationship between TC (R = -0.53; 95% CI [-0.61, -0.44]), TG (R = -0.50; 95% CI [-0.58, -0.41]), PL (R = -0.46; 95% CI [-0.54-0.36]), and TSL (R = -0.63; 95% CI [-0.69, -0.56]) with T/S. Our research suggests that the inverse relationship was found between TL and weight, BMI, age, and TSL which were associated with obesity. High serum lipids concentration may be associated with systemic inflammation and atherosclerosis and may lead to oxidative stress, resulting in telomere shortening.

SUBMITTER: Karimi B

PROVIDER: S-EPMC6457029 | biostudies-literature | 2019 Mar-Apr

REPOSITORIES: biostudies-literature

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Serum Level of Total Lipids and Telomere Length in the Male Population: A Cross-Sectional Study.

Karimi Behrooz B Yunesian Masud M Nabizadeh Ramin R Mehdipour Parvin P

American journal of men's health 20190301 2

Telomeres contain TTAGGG (T; Thymine, A; Adenine and G; Guanine) repetitive sequences and are placed at the end of human chromosomes. Telomere dysfunction is implicated in some age-related and chronic diseases, but its association with total serum lipids and obesity is unknown. Our objective was to determine influenced of total serum lipids on leukocyte telomere lengths (TLs). Participants were selected by cluster sampling from 22 districts of Tehran. The questionnaires were completed by 500 sub ...[more]

PMID: 30961458

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Project description:IMPORTANCE:Telomere length has been associated with dementia and psychological stress, but its relationship with human brain size is unknown. OBJECTIVE:To determine if peripheral blood telomere length is associated with brain volume. DESIGN, SETTING, AND PARTICIPANTS:Peripheral blood leukocyte telomere length and brain volumes were measured for 1960 individuals in the Dallas Heart Study, a population-based, probability sample of Dallas County, Texas, residents, with a median (25th-75th percentile) age of 50 (42-58) years. Global and 48 regional brain volumes were assessed from the automated analysis of magnetic resonance imaging. MAIN OUTCOMES AND MEASURES:Telomere length and global and regional brain volumes. RESULTS:Leukocyte telomere length was associated with total cerebral volume (? [SE], 0.06 [0.01], P?<.001) including white and cortical gray matter volume (? [SE], 0.04 [0.01], P?=?.002; ? [SE], 0.07 [0.02], P?<.001, respectively), independent of age, sex, ethnicity, and total intracranial volume. While age was associated with the size of most subsegmental regions of the cerebral cortex, telomere length was associated with certain subsegmental regions. Compared with age, telomere length (TL) explained a sizeable proportion of the variance in volume of the hippocampus, amygdala, and inferior temporal region (hippocampus: ?TL [SE], 0.08 [0.02], R2, 0.91% vs ?age [SE], -0.16 [0.02], R2, 3.80%; amygdala: ?TL [SE], 0.08 [0.02], R2, 0.78% vs ?age [SE],-0.19 [0.02], R2,4.63%; inferior temporal: ?TL [SE], 0.07 [0.02], R2, 0.92% vs ?age [SE], -0.14 [0.02], R2, 3.98%) (P?<.001 for all). The association of telomere length and the size of the inferior and superior parietal, hippocampus, and fusiform regions was stronger in individuals older than 50 years than younger individuals (inferior parietal: ?>50 [SE], 0.13 [0.03], P?<.001 vs ??50 [SE], 0.02 [0.02], P?=?.51, P for interaction = .001; superior parietal: ?>50 [SE], 0.11 [0.03], P?<.001 vs ??50 [SE], 0.01 [0.02], P?=?.71, P for interaction = .004; hippocampus: ?>50 [SE], 0.10 [0.03], P?=?.004 vs ??50 [SE], 0.05 [0.02], P?=?.07, P for interaction = .04; fusiform: ?>50 [SE], 0.09 [0.03], P?=?.002, ??50 [SE], 0.03 [0.02], P?=?.31, P for interaction = .03). The volume of the hippocampus, amygdala, superior and inferior temporal, precuneus, lateral orbitofrontal, posterior cingulate, thalamus and ventral diencephalon were independently associated with telomere length after adjustment for all covariates (age, gender, ethnicity, total intracranial volume, body mass index, blood pressure, diabetes, smoking status, and APOE genotype). CONCLUSIONS AND RELEVANCE:To our knowledge, this is the first population-based study to date to evaluate telomere length as an independent predictor of global and regional brain size. Future studies are needed to determine how telomere length and anatomic structural changes are related to cognitive function, dementia, and psychological disease.

Dataset Information

Serum Level of Total Lipids and Telomere Length in the Male Population: A Cross-Sectional Study.

Publications

Serum Level of Total Lipids and Telomere Length in the Male Population: A Cross-Sectional Study.

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