Genome-wide analysis of epigenetic dynamics across human developmental stages and tissues.

ABSTRACT:

Background

Epigenome is highly dynamic during the early stages of embryonic development. Epigenetic modifications provide the necessary regulation for lineage specification and enable the maintenance of cellular identity. Given the rapid accumulation of genome-wide epigenomic modification maps across cellular differentiation process, there is an urgent need to characterize epigenetic dynamics and reveal their impacts on differential gene regulation.

Methods

We proposed DiffEM, a computational method for differential analysis of epigenetic modifications and identified highly dynamic modification sites along cellular differentiation process. We applied this approach to investigating 6 epigenetic marks of 20 kinds of human early developmental stages and tissues, including hESCs

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6457072 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature