Ontology highlight
ABSTRACT:
SUBMITTER: Qin CX
PROVIDER: S-EPMC6457169 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Qin Cheng Xue CX Rosli Sarah S Deo Minh M Cao Nga N Walsh Jesse J Tate Mitchel M Alexander Amy E AE Donner Daniel D Horlock Duncan D Li Renming R Kiriazis Helen H Lee Man K S MKS Bourke Jane E JE Yang Yuan Y Murphy Andrew J AJ Du Xiao-Jun XJ Gao Xiao Ming XM Ritchie Rebecca H RH
Frontiers in pharmacology 20190403
The anti-inflammatory, pro-resolving annexin-A1 protein acts as an endogenous brake against exaggerated cardiac necrosis, inflammation, and fibrosis following myocardial infarction (MI) <i>in vivo</i>. Little is known, however, regarding the cardioprotective actions of the N-terminal-derived peptide of annexin A1, Ac<sub>2-26</sub>, particularly beyond its anti-necrotic actions in the first few hours after an ischemic insult. In this study, we tested the hypothesis that exogenous Ac<sub>2-26</su ...[more]