Ontology highlight
ABSTRACT:
SUBMITTER: Ballantine RD
PROVIDER: S-EPMC6457190 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ballantine Ross D RD McCallion Conor E CE Nassour Elie E Tokajian Sima S Cochrane Stephen A SA
MedChemComm 20190312 3
Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as d/l diaminobutyric acid and d-<i>allo</i>-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain ...[more]