Ontology highlight
ABSTRACT:
SUBMITTER: Bassan R
PROVIDER: S-EPMC6457212 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Bassan Renato R Intermesoli Tamara T Masciulli Arianna A Pavoni Chiara C Boschini Cristina C Gianfaldoni Giacomo G Marmont Filippo F Cavattoni Irene I Mattei Daniele D Terruzzi Elisabetta E De Paoli Lorella L Cattaneo Chiara C Borlenghi Erika E Ciceri Fabio F Bernardi Massimo M Scattolin Anna M AM Todisco Elisabetta E Campiotti Leonardo L Corradini Paolo P Cortelezzi Agostino A Ferrero Dario D Zanghì Pamela P Oldani Elena E Spinelli Orietta O Audisio Ernesta E Cortelazzo Sergio S Bosi Alberto A Falini Brunangelo B Pogliani Enrico M EM Rambaldi Alessandro A
Blood advances 20190401 7
Here we evaluated whether sequential high-dose chemotherapy (sHD) increased the early complete remission (CR) rate in acute myelogenous leukemia (AML) compared with standard-intensity idarubicin-cytarabine-etoposide (ICE) chemotherapy. This study enrolled 574 patients (age, 16-73 years; median, 52 years) who were randomly assigned to ICE (n = 286 evaluable) or sHD (2 weekly 3-day blocks with cytarabine 2 g/m<sup>2</sup> twice a day for 2 days plus idarubicin; n = 286 evaluable). Responsive patie ...[more]