Ontology highlight
ABSTRACT:
SUBMITTER: Flood DT
PROVIDER: S-EPMC6457263 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Flood Dillon T DT Yan Nicholas L NL Dawson Philip E PE
Angewandte Chemie (International ed. in English) 20180611 28
Amino-γ-lactam (Agl) bridged dipeptides, commonly known as Freidinger lactams, have been shown to constrain peptide backbone topology and stabilize type II' β-turns. The utility of these links as peptide constraints has inspired new approaches to their incorporation into complex peptides and peptoids, all of which require harsh reaction conditions or protecting groups that limit their use on unprotected peptides and proteins. Herein, we employ a mild and selective alkylation of selenomethionine ...[more]