Modular Antigen-Specific T-cell Biofactories for Calibrated In Vivo Synthesis of Engineered Proteins.
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ABSTRACT:
SUBMITTER: Repellin CE
PROVIDER: S-EPMC6457467 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
Modular Antigen-Specific T-cell Biofactories for Calibrated In Vivo Synthesis of Engineered Proteins.
Repellin Claire E CE Patel Puja P Beviglia Lucia L Javitz Harold H Sambucetti Lidia L Bhatnagar Parijat P
Advanced biosystems 20180914 12
An artificial cell-signaling pathway is developed that capitalizes on the T-cell's innate extravasation ability and transforms it into a vector (<i>T-cell Biofactory</i>) for synthesizing calibrated amounts of engineered proteins in vivo. The modularity of this pathway enables reprogramming of the <i>T-cell Biofactory</i> to target biomarkers on different disease cells, e.g. cancer, viral infections, autoimmune disorders. It can be expected that the <i>T-cell Biofactory</i> leads to a "living dr ...[more]
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