RNA Recognition-like Motifs Activate a Mitogen-Activated Protein Kinase.
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ABSTRACT:
SUBMITTER: Phillips T
PROVIDER: S-EPMC6457901 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Publications
RNA Recognition-like Motifs Activate a Mitogen-Activated Protein Kinase.
Phillips Timothy T Tio Chong Wai CW Omerza Gregory G Rimal Abhimannyu A Lokareddy Ravi K RK Cingolani Gino G Winter Edward E
Biochemistry 20181204 50
Smk1 is a mitogen-activated protein kinase (MAPK) family member in the yeast Saccharomyces cerevisiae that controls the postmeiotic program of spore formation. Ssp2 is a meiosis-specific protein that activates Smk1 and triggers the autophosphorylation of its activation loop. A fragment of Ssp2 that is sufficient to activate Smk1 contains two segments that resemble RNA recognition motifs (RRMs). Mutations in either of these motifs eliminated Ssp2's ability to activate Smk1. In contrast, deletions ...[more]
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