Ontology highlight
ABSTRACT:
SUBMITTER: Ye R
PROVIDER: S-EPMC6458522 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ye Risheng R Onodera Toshiharu T Blanchard Pierre-Gilles PG Kusminski Christine M CM Esser Victoria V Brekken Rolf A RA Scherer Philipp E PE
The American journal of pathology 20190114 4
Syntrophins are a family of proteins forming membrane-anchored scaffolds and serving as adaptors for various transmembrane and intracellular signaling molecules. To understand the physiological roles of β1 syntrophin, one of the least characterized members, we generated mouse models to eliminate β1 syntrophin specifically in the endocrine or exocrine pancreas. β1 syntrophin is dispensable for the morphology and function of insulin-producing β cells. However, mice with β1 syntrophin deletion in e ...[more]