Dataset Information

The aorta after coarctation repair - effects of calibre and curvature on arterial haemodynamics.

ABSTRACT:

Background

Aortic shape has been proposed as an important determinant of adverse haemodynamics following coarctation repair. However, previous studies have not demonstrated a consistent relationship between shape and vascular load. In this study, 3D aortic shape was evaluated using principal component analysis (PCA), allowing investigation of the relationship between 3D shape and haemodynamics.

Methods

Sixty subjects (38 male, 25.0?±?7.8?years) with repaired coarctation were recruited. Central aortic haemodynamics including wave intensity analysis were measured noninvasively using a combination of blood pressure and phase contrast cardiovascular magnetic resonance (CMR). 3D curvature and radius data were derived from CMR angiograms. PCA was separately performed on 3D radius and curvature data to assess the role of arch geometry on haemodynamics. Clinical findings were corroborated using 1D vascular models.

Results

There were no independent associations between 3D curvature and any hemodynamic parameters. However, the magnitude of the backwards compression wave was related to the 1st (r?=?-?0.36, p =?0.005), 3rd (r?=?0.27, p =?0.036) and 4th (r?=?-?0.31, p =?0.017) principle components of radius. The 4th principle componentof radius also correlated with central aortic systolic pressure. These aortas had larger aortic roots, more transverse arch hypoplasia and narrower aortic isthmuses.

Conclusions

There are major modes of variation in 3D aortic shape after coarctation repair witha modest association between variation in aortic radius and pathological wave reflections, but not with 3D curvature. Taken together, these data suggest that shape is not the major determinant of vascular load following coarctation repair, and calibre is more important than curvature.

SUBMITTER: Quail MA

PROVIDER: S-EPMC6458643 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

The aorta after coarctation repair - effects of calibre and curvature on arterial haemodynamics.

Quail Michael A MA Segers Patrick P Steeden Jennifer A JA Muthurangu Vivek V

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20190411 1

<h4>Background</h4>Aortic shape has been proposed as an important determinant of adverse haemodynamics following coarctation repair. However, previous studies have not demonstrated a consistent relationship between shape and vascular load. In this study, 3D aortic shape was evaluated using principal component analysis (PCA), allowing investigation of the relationship between 3D shape and haemodynamics.<h4>Methods</h4>Sixty subjects (38 male, 25.0 ± 7.8 years) with repaired coarctation were recru ...[more]

PMID: 30975162

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Dataset Information

The aorta after coarctation repair - effects of calibre and curvature on arterial haemodynamics.

Background

Methods

Results

Conclusions

Publications

The aorta after coarctation repair - effects of calibre and curvature on arterial haemodynamics.

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