TNF? inhibitors as targets for protective therapies in MSA: a viewpoint.
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ABSTRACT:
SUBMITTER: Ndayisaba A
PROVIDER: S-EPMC6458780 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
TNFα inhibitors as targets for protective therapies in MSA: a viewpoint.
Ndayisaba Alain A Jellinger Kurt K Berger Thomas T Wenning Gregor K GK
Journal of neuroinflammation 20190411 1
Multiple system atrophy (MSA) is a unique and fatal α-synucleinopathy associated with oligodendroglial inclusions and secondary neurodegeneration affecting striatum, substantia nigra, pons, and cerebellum. The pathogenesis remains elusive; however, there is emerging evidence suggesting a prominent role of neuroinflammation. Here, we critically review the relationship between αS and microglial activation depending on its aggregation state and its role in neuroinflammation to explore the potential ...[more]
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