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The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.


ABSTRACT: The enzymology of 135 assembly lines containing primarily cis-acyltransferase modules is comprehensively analyzed, with greater attention paid to less common phenomena. Diverse online transformations, in which the substrate and/or product of the reaction is an acyl chain bound to an acyl carrier protein, are classified so that unusual reactions can be compared and underlying assembly-line logic can emerge. As a complement to the chemistry surrounding the loading, extension, and offloading of assembly lines that construct primarily polyketide products, structural aspects of the assembly-line machinery itself are considered. This review of assembly-line phenomena, covering the literature up to 2017, should thus be informative to the modular polyketide synthase novice and expert alike.

SUBMITTER: Keatinge-Clay AT 

PROVIDER: S-EPMC6459028 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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The Uncommon Enzymology of Cis-Acyltransferase Assembly Lines.

Keatinge-Clay Adrian T AT  

Chemical reviews 20170410 8


The enzymology of 135 assembly lines containing primarily cis-acyltransferase modules is comprehensively analyzed, with greater attention paid to less common phenomena. Diverse online transformations, in which the substrate and/or product of the reaction is an acyl chain bound to an acyl carrier protein, are classified so that unusual reactions can be compared and underlying assembly-line logic can emerge. As a complement to the chemistry surrounding the loading, extension, and offloading of ass  ...[more]

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