Ontology highlight
ABSTRACT:
SUBMITTER: Ingham NJ
PROVIDER: S-EPMC6459510 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
PLoS biology 20190411 4
Adult-onset hearing loss is very common, but we know little about the underlying molecular pathogenesis impeding the development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response (ABR). We review here the findings from this screen. Thirty-eight unexpected genes associated with raised thresholds were detected from our u ...[more]