Ontology highlight
ABSTRACT:
SUBMITTER: Rogers C
PROVIDER: S-EPMC6459836 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Rogers Corey C Erkes Dan A DA Nardone Alexandria A Aplin Andrew E AE Fernandes-Alnemri Teresa T Alnemri Emad S ES
Nature communications 20190411 1
Gasdermin E (GSDME/DFNA5) cleavage by caspase-3 liberates the GSDME-N domain, which mediates pyroptosis by forming pores in the plasma membrane. Here we show that GSDME-N also permeabilizes the mitochondrial membrane, releasing cytochrome c and activating the apoptosome. Cytochrome c release and caspase-3 activation in response to intrinsic and extrinsic apoptotic stimuli are significantly reduced in GSDME-deficient cells comparing with wild type cells. GSDME deficiency also accelerates cell gro ...[more]