Ontology highlight
ABSTRACT:
SUBMITTER: Scherma M
PROVIDER: S-EPMC6460372 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Scherma Maria M Masia Paolo P Satta Valentina V Fratta Walter W Fadda Paola P Tanda Gianluigi G
Acta pharmacologica Sinica 20180726 3
Anandamide is a lipid mediator that acts as an endogenous ligand of CB1 receptors. These receptors are also the primary molecular target responsible for the pharmacological effects of Δ9-tetrahydrocannabinol, the psychoactive ingredient in Cannabis sativa. Several studies demonstrate that anandamide exerts an overall modulatory effect on the brain reward circuitry. Several reports suggest its involvement in the addiction-producing actions of other abused drugs, and it can also act as a behaviora ...[more]