The impact of early-life intelligence quotient on post stroke cognitive impairment.
Ontology highlight
ABSTRACT: Background
Cognitive impairment can complicate minor stroke, but there is limited information on risk factors including peak cognitive ability earlier in life.Methods
We recruited patients with clinically-evident lacunar or minor non-lacunar ischaemic stroke, recorded clinical features, vascular risk factors, magnetic resonance imaging-detected stroke sub-type and small vessel disease burden. At 1-3 and 12 months after stroke, we assessed educational attainment (years of education), current cognition (Addenbrooke's Cognitive Examination-Revised), pre-morbid intelligence (National Adult Reading Test) and dependency (modified Rankin Scale).Results
We recruited 157 patients (87 lacunar, 64 non-lacunar ischaemic strokes), median age 66 (inter-quartile range 56-74) years, 36/157 (23%) patients had a Addenbrooke's Cognitive Examination-Revised score?DiscussionThis observational study provides evidence that pre-morbid intelligence quotient and education predict cognition after stroke, and confirms the association between cognitive impairment and small vessel disease.Conclusion
Pre-morbid intelligence should be considered in future studies of post-stroke cognition.
SUBMITTER: Makin SD
PROVIDER: S-EPMC6460404 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Publications
The impact of early-life intelligence quotient on post stroke cognitive impairment.
Makin Stephen Dj SD Doubal Fergus N FN Shuler Kirsten K Chappell Francesca M FM Staals Julie J Dennis Martin S MS Wardlaw Joanna M JM
European stroke journal 20180108 2
<h4>Background</h4>Cognitive impairment can complicate minor stroke, but there is limited information on risk factors including peak cognitive ability earlier in life.<h4>Methods</h4>We recruited patients with clinically-evident lacunar or minor non-lacunar ischaemic stroke, recorded clinical features, vascular risk factors, magnetic resonance imaging-detected stroke sub-type and small vessel disease burden. At 1-3 and 12 months after stroke, we assessed educational attainment (years of educatio ...[more]
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