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Relationship between the muscle relaxation effect and body muscle mass measured using bioelectrical impedance analysis: A nonrandomized controlled trial.


ABSTRACT: OBJECTIVE:The dose of neuromuscular blocking drugs is commonly based on body weight, but using muscle mass might be more effective. This study investigated the relationship between the effect of neuromuscular blocking drugs and muscle mass measured using bioelectrical impedance analysis. METHODS:Patients who were scheduled for elective surgery using a muscle relaxant were screened for inclusion in this study. Under intravenous anaesthesia, 12 mg or 9 mg of rocuronium was administered to males and females, respectively; and the maximal relaxation effect of T1 was measured using a TOF-Watch-SX® acceleromyograph. RESULTS:This study enrolled 40 patients; 20 males and 20 females. For both sexes, the maximal relaxation effect of T1 did not correlate with the body weight-based dose of neuromuscular blocking drugs (males, r2?=?0.12; females, r2?=?0.26). Instead, it correlated with the dose based on bioelectrical impedance analysis-measured muscle mass when injected with the same dose of rocuronium (males, r2?=?0.78, female, r2?=?0.82). CONCLUSIONS:This study showed that the muscle relaxation effect of rocuronium was correlated with muscle mass and did not correlate with body weight when using the same dose. Therefore, a muscle mass-based dose of neuromuscular blocking drugs is recommended.

SUBMITTER: Choi YJ 

PROVIDER: S-EPMC6460603 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Relationship between the muscle relaxation effect and body muscle mass measured using bioelectrical impedance analysis: A nonrandomized controlled trial.

Choi Yoon-Ji YJ   Hee Kim Yun Y   Bae Go Eun GE   Yu Joon Ho JH   Yoon Seung Zhoo SZ   Kang Hee Won HW   Lee Kuen Su KS   Kim Jae-Hwan JH   Lee Yoon-Sook YS  

The Journal of international medical research 20190205 4


<h4>Objective</h4>The dose of neuromuscular blocking drugs is commonly based on body weight, but using muscle mass might be more effective. This study investigated the relationship between the effect of neuromuscular blocking drugs and muscle mass measured using bioelectrical impedance analysis.<h4>Methods</h4>Patients who were scheduled for elective surgery using a muscle relaxant were screened for inclusion in this study. Under intravenous anaesthesia, 12 mg or 9 mg of rocuronium was administe  ...[more]

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