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HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis.

ABSTRACT: Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papilloma virus (HPV) status has gained acceptance. To combat the constantly growing epidemic of HPV+ oropharyngeal cancer, further investigation and characterization the unique features of the disease, along with the development and implementation of new, targeted therapies, is crucial. In this review, we summarize the etiology, pathogenesis, diagnosis, treatment, and molecular characteristics of HPV-associated oropharyngeal squamous cell carcinoma.

SUBMITTER: Pan C

PROVIDER: S-EPMC6460765 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis.

Pan Cassie C Issaeva Natalia N Yarbrough Wendell G WG

Cancers of the head & neck 20181229

Understanding of oropharyngeal squamous cell carcinoma has significantly progressed over the last decades, and the concept that this disease can be subdivided into two distinct entities based on human papilloma virus (HPV) status has gained acceptance. To combat the constantly growing epidemic of HPV+ oropharyngeal cancer, further investigation and characterization the unique features of the disease, along with the development and implementation of new, targeted therapies, is crucial. In this re ...[more]

PMID: 31093365

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HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.

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