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Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation.

ABSTRACT: Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

SUBMITTER: Ammitzboll C

PROVIDER: S-EPMC6461219 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation.

Ammitzbøll Cecilie C Börnsen Lars L Petersen Eva Rosa ER Oturai Annette Bang AB Søndergaard Helle Bach HB Grandjean Philippe P Sellebjerg Finn F

Journal of neuroimmunology 20190302

Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found tha ...[more]

PMID: 30852181

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